Methylene Blue for Brain Health

Perhaps one of the most revolutionary benefits of methylene blue is for the prevention and treatment of dementia, neurodegenerative diseases such as Alzheimer’s and Parkinson’s, and neural injuries caused by stroke and traumatic brain injuries (TBIs). This is particularly important as the COVID jabs have radically increased strokes.

“Any process where increasing oxygen-based energy production plays a major role, methylene blue will have a role to play. One of the first studies we did that was very impressive [was on] a model in the eye. The reason we used the eye was because the retina in animals is readily accessible so that we can inject into the retina.

Rotenone [a broad-spectrum pesticide and Complex 1 inhibitor] inhibits mitochondrial respiration, subsequently there is atrophy and degeneration of the retinal layer, which is very dramatic. If methylene blue is on board, we can prevent this process because the mitochondrial respiration can continue, so the tissue is not affected.

This was a model called an optic neuropathy due to mitochondrial defects. It’s the most common form of blindness in younger people, so we did this to verify in vivo that [methylene blue] could have this neuroprotective effect. Then it was performed in other things like brains. Similar phenomenon was discovered ...

Methylene blue can be protective in ischemic and hemorrhagic strokes and hypoxia. In other words, there was a reduced amount of oxygen delivered to the animals, and with the use an fMRI, noninvasively, in the animals to see that there was an increase in the amount of cerebral metabolic rate for oxygen consumption in the presence of methylene blue under hypoxic conditions.

With respect to dementia, by the time you see the tau protein inside neurons, those neurons are metabolically, essentially, dead, so it is too late. By acting on that, you cannot recover the metabolic machinery and the health of the neurons.

So, those neurons are not rescued in any way that is functionally meaningful. Generally speaking, biomarkers are not good therapeutic targets because they may or may not have any causal relationship with the disease.”

In biohacker circles, low-dose methylene blue is used as a nootropic, meaning a compound that helps improve cognitive function. However, while some promote sublingual or buccal application (under your tongue or on the inside of your cheek), the best way is to swallow it, as the acid in your stomach makes it more bioavailable.